- Sadsbury Township
- St Clair
- St Peters
- Salem
- Salem Township
- Salford
- Salford Township
- Salfordville
- Salisbury
- Salix
- Salona
- Sandy
- Sandy Ridge
- Sandy Township
- Sankertown
- Sassamansville
- Saville Township
- Saw Creek
- Saxton
- Saylorsburg
- Sayre
- Schellsburg
- Schlusser
- Schnecksville
- Schuylkill
- Schuylkill Haven
- Schwenksville
- Sciota
- Scotrun
- Scott
- Scottdale
- Scranton
- Seanor
- Secane
- Selinsgrove
- Sellersville
- Seltzer
- Sewickley
- Shady Grove
- Shamokin
- Sharon
- Sharon Hill
- Shartlesville
- Shavertown
- Shawnee On Delaware
- Shenandoah
- Sheppton
- Shermans Dale
- Sheshequin Township
- Shickshinny
- Shippensburg
- Shippensburg Township
- Shirleysburg
- Shoemakersville
- Shohola
- Shohola Township
- Shrewsbury Township
- Sierra View
- Siles
- Silver Spring
- Silver Spring Township
- Silverdale
- Skippack
- Skippack Township
- Skytop
- Slatedale
- Slatington
- Slippery Rock
- Smithmill
- Smoketown
- Snow Shoe
- Snydersville
- Snydertown
- Solebury
- Solebury Township
- Somerset
- Somerset Township
- Souderton
- South Canaan
- South Fork
- South Lebanon Township
- South Philipsburg
- South Sterling
- South Uniontown
- Southampton
- Spinnerstown
- Spring City
- Spring Garden
- Spring Grove
- Spring Hill
- Spring House
- Spring Mills
- Spring Mt
- Spring Ridge
- Spring Township
- Springettsbury Township
- Springfield
- Springtown
- Springville
- Sproul
- Spruce Creek
- Spruce Hill Township
- Starlight
- State College
- State Line
- Sterling
- Stevens
- Stewartstown
- Stockertown
- Strausstown
- Stroud
- Stroudsburg
- Sugarcreek
- Sugarloaf
- Sugarloaf Township
- Summerdale
- Summerhill
- Summerhill Township
- Summit Hill
- Sumneytown
- Sunbury
- Susquehanna
- Susquehanna Depot
- Swarthmore
- Swatara Township
- Swiftwater